Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions characterized by early-onset difficulties in social communication and unusually restricted, repetitive behavior and interests. There has been substantial recent research on ASD. Magnetoencephalography (MEG) is used in ASD research for its noninvasive nature of recordings and for its excellent temporal and spatial resolution. The number of MEG-based ASD studies in children is increasing with larger study groups. Furthermore, the analyses are becoming more sophisticated. Research over the last several decades using MEG has identified consistent atypical electrophysiological signatures of ASD, indicating common neural circuit disruptions, such as reduced long-range resting-state neural connectivity. In addition, auditory processing MEG signatures, such as middle-latency response (M50/M100) and gamma-band oscillatory activity, hold particular promise in the study and treatment of ASD and as candidate biomarkers of ASD. With the development of MEG customized for a child’s head, some studies even include children younger than 3 years of age. Thus, future studies investigating these MEG signatures across developmental stages are expected to reveal the underlying neurobiology of ASD and may uncover new avenues of treatments for ASD.
All Science Journal Classification (ASJC) codes
- General Medicine
- General Neuroscience