TY - JOUR
T1 - Augmented secretion of brain natriuretic peptide in acute myocardial infarction
AU - Mukoyama, Masashi
AU - Nakao, Kazuwa
AU - Obata, Kenji
AU - Jougasaki, Michihisa
AU - Yoshimura, Michihiro
AU - Morita, Etsuo
AU - Hosoda, Kiminori
AU - Suga, Shin ichi
AU - Ogawa, Yoshihiro
AU - Yasue, Hirofumi
AU - Imura, Hiroo
N1 - Funding Information:
We cordially thank Ms. A. Kibune and MS. S. Takahashi for their secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Educaticn, Science and Culture, the Japanese Ministry of H~alth and Welfare "Disorders of Adrenal Hormone" Research Committee, Japan, 1990, Japan Tobacco Inc., Yamanouchi Foundation for Pesearch on Metabolic Disorders, the Cell Science Research Foundation, 1990, Uehara Memorial Foundation, and by research grants for cardiovascular diseases (63C-2 and 2A-3) from the Japanese Ministry of Health and Welfare.
PY - 1991/10/15
Y1 - 1991/10/15
N2 - In order to elucidate biosynthesis and secretion of natriuretic peptides in the early phase of acute myocardial infarction (AMI), we measured the plasma level of brain natriuretic peptide (BNP), a novel cardiac hormone secreted from the ventricle, in patients with AMI and compared with that of atrial natriuretic peptide (ANP). The plasma level of BNP increased rapidly (within hours from the onset of AMI) and markedly (>100 times the normal level) as compared to that of ANP. The plasma ANP level correlated with pulmonary capillary wedge pressure (PCWP), whereas the plasma BNP level did not correlate with PCWP but highly correlated inversely with cardiac index. These results indicate that BNP is secreted from the heart much more acutely and prominently than ANP in the early phase of AMI, in association with left ventricular dysfunction.
AB - In order to elucidate biosynthesis and secretion of natriuretic peptides in the early phase of acute myocardial infarction (AMI), we measured the plasma level of brain natriuretic peptide (BNP), a novel cardiac hormone secreted from the ventricle, in patients with AMI and compared with that of atrial natriuretic peptide (ANP). The plasma level of BNP increased rapidly (within hours from the onset of AMI) and markedly (>100 times the normal level) as compared to that of ANP. The plasma ANP level correlated with pulmonary capillary wedge pressure (PCWP), whereas the plasma BNP level did not correlate with PCWP but highly correlated inversely with cardiac index. These results indicate that BNP is secreted from the heart much more acutely and prominently than ANP in the early phase of AMI, in association with left ventricular dysfunction.
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U2 - 10.1016/S0006-291X(05)81311-7
DO - 10.1016/S0006-291X(05)81311-7
M3 - Article
C2 - 1834057
AN - SCOPUS:0026066730
SN - 0006-291X
VL - 180
SP - 431
EP - 436
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -