Augmented secretion of brain natriuretic peptide in acute myocardial infarction

Masashi Mukoyama, Kazuwa Nakao, Kenji Obata, Michihisa Jougasaki, Michihiro Yoshimura, Etsuo Morita, Kiminori Hosoda, Shin ichi Suga, Yoshihiro Ogawa, Hirofumi Yasue, Hiroo Imura

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114 Citations (Scopus)


In order to elucidate biosynthesis and secretion of natriuretic peptides in the early phase of acute myocardial infarction (AMI), we measured the plasma level of brain natriuretic peptide (BNP), a novel cardiac hormone secreted from the ventricle, in patients with AMI and compared with that of atrial natriuretic peptide (ANP). The plasma level of BNP increased rapidly (within hours from the onset of AMI) and markedly (>100 times the normal level) as compared to that of ANP. The plasma ANP level correlated with pulmonary capillary wedge pressure (PCWP), whereas the plasma BNP level did not correlate with PCWP but highly correlated inversely with cardiac index. These results indicate that BNP is secreted from the heart much more acutely and prominently than ANP in the early phase of AMI, in association with left ventricular dysfunction.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Oct 15 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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