Augmentation of the resistance against listeria monocytogenes by oral administration of a hot water extt of chlorella vulgarism mice

Takashi Hasegawa, Masao Okuda, Kikuo Nomoto, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Oral administration of a hot water extract of Chlorella vulgaris(CVE)(20mg/mouse, 10 consecutive days) augmented the resistance against an i.p. infection with Listeria monocytogenes in mice. The numbers of bacteria in a CVE-administered group were significantly lower in the peritoneal cavity or spleen than those in a control group. FCM analysis revealed that γdelta;±Thy 1.2± cells in the nonadherent PEC from CVE-administered mice increased more prominently in number at the early stage on day 3 or on day 5 after infection as compared with those in control mice. The increment of γdelta;±Thy 1.2± T cells was also evident in spleen in CVE-administered mice at this stage after infection. The proportion of TCRαbeta;plusmn;Thy 1.2± T cells in the nonadherent PEC of a control group increased from 13% on day 0 to 49% at the late stage on day 10 after infection, whereas the proportion of TCRαbeta;±Thy 1.2± T cells in the nonadherent PEC in CVE-administered mice increased to 64% on this stage after infection in association with augmentation of DTH response to Listeria. These results suggest that CVE-administration effectively augment cell-mediated immunity against Listeria through the increment of γdelta;± T cells in the early phase and the increment of αbeta;± T cells in the late phase after listerial infection.

Original languageEnglish
Pages (from-to)191-202
Number of pages12
JournalImmunopharmacology and Immunotoxicology
Volume16
Issue number2
DOIs
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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