TY - JOUR
T1 - Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells
AU - Arinobu, Yojiro
AU - Sugimoto, Rie
AU - Akaiwa, Mina
AU - Arima, Kazuhiko
AU - Otsuka, Takeshi
AU - Hamasaki, Naotaka
AU - Izuhara, Kenji
N1 - Funding Information:
We thank Dr. Dovie R. Wylie for the critical review of this manuscript. This work was supported in part by a Research Grant for Immunology, Allergy, and Organ Transplant from the Ministry of Health and Welfare of Japan and a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.
PY - 2000/10/22
Y1 - 2000/10/22
N2 - Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells. (C) 2000 Academic Press.
AB - Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells. (C) 2000 Academic Press.
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U2 - 10.1006/bbrc.2000.3674
DO - 10.1006/bbrc.2000.3674
M3 - Article
C2 - 11032724
AN - SCOPUS:0034703636
SN - 0006-291X
VL - 277
SP - 317
EP - 324
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -