Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901

Makoto Tanaka, Hiroyuki Miyazaki, Yasuyuki Takeda, Suguru Takeo, Yasunobu Yoshikai, Kikuo Nomoto

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6 Citations (Scopus)

Abstract

The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.

Original languageEnglish
Pages (from-to)403-420
Number of pages18
JournalImmunopharmacology and Immunotoxicology
Volume14
Issue number3
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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