TY - JOUR
T1 - Auditory sensory gating to the human voice
T2 - A preliminary MEG study
AU - Hirano, Yoji
AU - Onitsuka, Toshiaki
AU - Kuroki, Toshihide
AU - Matsuki, Yuji
AU - Hirano, Shogo
AU - Maekawa, Toshihiko
AU - Kanba, Shigenobu
N1 - Funding Information:
This work was supported in part by a grant-in-aid for Scientific Research (C17591218) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (to Dr. Onitsuka). The authors gratefully acknowledge the valuable technical assistance of Mr. Kazumitsu Takahashi and Miss Yuko Somehara.
PY - 2008/8/30
Y1 - 2008/8/30
N2 - The ability of the brain to suppress incoming irrelevant sensory input is termed 'sensory gating,' and auditory sensory gating is often indexed by the auditory evoked response. We recorded the auditory evoked magnetic fields to the human voice, using the conditioning-testing paradigm, to investigate whether or not healthy subjects show less activation to the second voice stimulus. Seventeen healthy adults (mean age 27.9 ± 4.8 years, 9 males and 8 females) participated in the experiment. The auditory stimuli were presented monaurally as a series of 120 paired voices, with 500-ms interstimulus intervals and 6-s interpaired stimulus intervals. The P50m and the N100m responses were investigated, and dipole source localization was performed. Root mean squares of both P50m and N100m were significantly suppressed to the second stimulus bilaterally, and the suppression was more significant in N100m. The N100m was located significantly more laterally than the P50m for both hemispheres. These results therefore demonstrate the presence of sensory gating for auditory inputs of the human voice in the primary auditory cortex and the auditory association area.
AB - The ability of the brain to suppress incoming irrelevant sensory input is termed 'sensory gating,' and auditory sensory gating is often indexed by the auditory evoked response. We recorded the auditory evoked magnetic fields to the human voice, using the conditioning-testing paradigm, to investigate whether or not healthy subjects show less activation to the second voice stimulus. Seventeen healthy adults (mean age 27.9 ± 4.8 years, 9 males and 8 females) participated in the experiment. The auditory stimuli were presented monaurally as a series of 120 paired voices, with 500-ms interstimulus intervals and 6-s interpaired stimulus intervals. The P50m and the N100m responses were investigated, and dipole source localization was performed. Root mean squares of both P50m and N100m were significantly suppressed to the second stimulus bilaterally, and the suppression was more significant in N100m. The N100m was located significantly more laterally than the P50m for both hemispheres. These results therefore demonstrate the presence of sensory gating for auditory inputs of the human voice in the primary auditory cortex and the auditory association area.
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U2 - 10.1016/j.pscychresns.2007.07.002
DO - 10.1016/j.pscychresns.2007.07.002
M3 - Article
C2 - 18650072
AN - SCOPUS:48749126538
SN - 0925-4927
VL - 163
SP - 260
EP - 269
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -
