TY - JOUR
T1 - Auditory gating deficit to human voices in schizophrenia
T2 - A MEG study
AU - Hirano, Yoji
AU - Hirano, Shogo
AU - Maekawa, Toshihiko
AU - Obayashi, Choji
AU - Oribe, Naoya
AU - Monji, Akira
AU - Kasai, Kiyoto
AU - Kanba, Shigenobu
AU - Onitsuka, Toshiaki
N1 - Funding Information:
This work was partially supported by grants-in-aid for Scientific Research ( C20591411 to Dr. Onitsuka and B19390306 to Dr. Kanba) from the Ministry of Education, Culture, Sports, Science and Technology , Japan, and a grant from Ministry of Health, Labor and Welfare , Japan ( H18 kokoro-ippan-012 to Dr. Kanba). The Ministry of Education, Culture, Sports, Science and Technology, and the Ministry of Health, Labor and Welfare had no further role in study design; in the collection, analysis and interpretation of data; in the writing report; and in the decision to submit the paper for publication.
PY - 2010/3
Y1 - 2010/3
N2 - Background: Patients with schizophrenia have auditory gating deficits; however, little is known about P50 auditory gating to human voices and its association with clinical symptoms. We examined the functioning of auditory gating and its relationship with the clinical symptoms in schizophrenia. Methods: Auditory evoked magnetoencephalography responses to the first and the second voices stimuli were recorded in 22 schizophrenia patients and 28 normal control subjects. The auditory gating ratios of P50m and N100m were investigated and P50m-symptom correlations were also investigated. Results: Patients showed significantly higher P50m gating ratios to human voices specifically in the left hemisphere. Moreover, patients with higher left P50m gating ratios showed more severe auditory hallucinations, while patients with higher right P50m gating ratios showed more severe negative symptoms. Conclusions: The present study suggests that schizophrenia patients have auditory gating deficits to human voices, specifically in the left hemisphere and auditory hallucinations of schizophrenia may be associated with sensory overload to human voices in the auditory cortex.
AB - Background: Patients with schizophrenia have auditory gating deficits; however, little is known about P50 auditory gating to human voices and its association with clinical symptoms. We examined the functioning of auditory gating and its relationship with the clinical symptoms in schizophrenia. Methods: Auditory evoked magnetoencephalography responses to the first and the second voices stimuli were recorded in 22 schizophrenia patients and 28 normal control subjects. The auditory gating ratios of P50m and N100m were investigated and P50m-symptom correlations were also investigated. Results: Patients showed significantly higher P50m gating ratios to human voices specifically in the left hemisphere. Moreover, patients with higher left P50m gating ratios showed more severe auditory hallucinations, while patients with higher right P50m gating ratios showed more severe negative symptoms. Conclusions: The present study suggests that schizophrenia patients have auditory gating deficits to human voices, specifically in the left hemisphere and auditory hallucinations of schizophrenia may be associated with sensory overload to human voices in the auditory cortex.
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U2 - 10.1016/j.schres.2009.09.003
DO - 10.1016/j.schres.2009.09.003
M3 - Article
C2 - 19783406
AN - SCOPUS:75749140091
SN - 0920-9964
VL - 117
SP - 61
EP - 67
JO - Schizophrenia research
JF - Schizophrenia research
IS - 1
ER -
