@article{d214babb79654a6ebb402ca3c25aa4bb,
title = "ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis",
abstract = "Ataxia-telangiectasia (A-T) patients occasionally develop diabetes mellitus. However, only limited attempts have been made to gain insight into the molecular mechanism of diabetes mellitus development in A-T patients. We found that Atm-/- mice were insulin resistant and possessed less subcutaneous adipose tissue as well as a lower level of serum adiponectin than Atm+/+ mice. Furthermore, invitro studies revealed impaired adipocyte differentiation in Atm-/- cells caused by the lack of induction of C/EBPα and PPARγ, crucial transcription factors involved in adipocyte differentiation. Interestingly, ATM was activated by stimuli that induced differentiation, and the binding of ATM to C/EBPβ and p300 was involved in the transcriptional regulation of C/EBPα and adipocyte differentiation. Thus, our study sheds light on the poorly understood role of ATM in the pathogenesis of glucose intolerance in A-T patients and providesinsight into the role of ATM in glucose metabolism.",
author = "Masatoshi Takagi and Hatsume Uno and Rina Nishi and Masataka Sugimoto and Setsuko Hasegawa and Jinhua Piao and Norimasa Ihara and Sayaka Kanai and Saori Kakei and Yoshifumi Tamura and Takayoshi Suganami and Yasutomi Kamei and Toshiaki Shimizu and Akio Yasuda and Yoshihiro Ogawa and Shuki Mizutani",
note = "Funding Information: This study was supported by a Grant-in-Aid from the Ministry of Education, Science, and Culture (grant 11939625), the Ministry of Health, Labor, and Welfare (grant 26310401), the Uehara Foundation, the Sumitomo Foundation, Morinaga Hoshikai, the Takeda Science Foundation, the Suzuken Memorial Foundation, and the Boshi Hoken Kyokai Foundation. We thank Atsuko Nishikawa for technical assistance. The Atm knockout mouse was kindly provided by Dr. Peter McKinnon (St. Jude Children{\textquoteright}s Research Hospital, Memphis, TN). The Atm +/+ and Atm −/− MEF cell lines were kindly provided by Dr. Charles Sherr (St. Jude Children{\textquoteright}s Research Hospital). We thank Hikari Taka and Tsutomu Fujimura (Juntendo University, Tokyo) for performing the LC-MS analysis. We thank Kevin Urayama (Tokyo Medical and Dental University) for critical reading of the manuscript. Publisher Copyright: {\textcopyright} 2015 The Authors.",
year = "2015",
month = feb,
day = "17",
doi = "10.1016/j.celrep.2015.01.027",
language = "English",
volume = "10",
pages = "957--967",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "6",
}