Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry

Ryosuke Kawakami; Yoshiaki Shinohara; Yuichiro Kato; Hiroyuki Sugiyama; Ryuichi Shigemoto; Isao Ito

doi:10.1126/science.1082609

Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry

Ryosuke Kawakami, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, Isao Ito

Biology, Faculty of Science

Research output: Contribution to journal › Article › peer-review

178 Citations (Scopus)

Abstract

Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

Original language	English
Pages (from-to)	990-994
Number of pages	5
Journal	Science
Volume	300
Issue number	5621
DOIs	https://doi.org/10.1126/science.1082609
Publication status	Published - May 9 2003

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AU - Kawakami, Ryosuke

AU - Shinohara, Yoshiaki

AU - Kato, Yuichiro

AU - Sugiyama, Hiroyuki

AU - Shigemoto, Ryuichi

AU - Ito, Isao

PY - 2003/5/9

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N2 - Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

AB - Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

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Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry

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