Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer

Hiroyuki Akita; Hiroko Matsukura; Takeshi Oishi; Atsuo Tanaka; Kenji Sonomoto

doi:10.1248/cpb.35.4985

Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer

Hiroyuki Akita, Hiroko Matsukura, Takeshi Oishi, Atsuo Tanaka, Kenji Sonomoto

Systems Biology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Asymmetric reduction of a-methyl β-keto esters using microbial cells immobilized by the prepolymer method was examined. It was found that by a proper selection of the prepolymer in the stage of immobilization, the chemical and optical yields were both improved appreciably in some cases compared to those obtained by reduction with the native microorganisms.

Original language	English
Pages (from-to)	4985-4987
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	12
DOIs	https://doi.org/10.1248/cpb.35.4985
Publication status	Published - 1987

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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abstract = "Asymmetric reduction of a-methyl β-keto esters using microbial cells immobilized by the prepolymer method was examined. It was found that by a proper selection of the prepolymer in the stage of immobilization, the chemical and optical yields were both improved appreciably in some cases compared to those obtained by reduction with the native microorganisms.",

author = "Hiroyuki Akita and Hiroko Matsukura and Takeshi Oishi and Atsuo Tanaka and Kenji Sonomoto",

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AU - Akita, Hiroyuki

AU - Matsukura, Hiroko

AU - Oishi, Takeshi

AU - Tanaka, Atsuo

AU - Sonomoto, Kenji

PY - 1987

Y1 - 1987

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AB - Asymmetric reduction of a-methyl β-keto esters using microbial cells immobilized by the prepolymer method was examined. It was found that by a proper selection of the prepolymer in the stage of immobilization, the chemical and optical yields were both improved appreciably in some cases compared to those obtained by reduction with the native microorganisms.

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Asymmetric Reduction of α-Methyl β-Keto Esters by Microbial Cells Immobilized with Prepolymer

Abstract

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