Asymmetric oxidative coupling of hydroxycarbazoles: Facile synthesis of (+)-bi-2-hydroxy-3-methylcarbazole

Makoto Sako; Akimasa Sugizaki; Shinobu Takizawa

doi:10.1016/j.bmcl.2018.02.033

Asymmetric oxidative coupling of hydroxycarbazoles: Facile synthesis of (+)-bi-2-hydroxy-3-methylcarbazole

Makoto Sako, Akimasa Sugizaki, Shinobu Takizawa

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Asymmetric oxidative coupling reactions of hydroxycarbazoles have been established using a chiral dinuclear vanadium complex. To demonstrate the utility of vanadium-catalyzed reactions, we have used them to synthesize (+)-bi-2-hydroxy-3-carbazole in three steps from cyclohexanone and commercially available aniline derivatives.

Original language	English
Pages (from-to)	2751-2753
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	28
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2018.02.033
Publication status	Published - Sept 1 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2018.02.033

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abstract = "Asymmetric oxidative coupling reactions of hydroxycarbazoles have been established using a chiral dinuclear vanadium complex. To demonstrate the utility of vanadium-catalyzed reactions, we have used them to synthesize (+)-bi-2-hydroxy-3-carbazole in three steps from cyclohexanone and commercially available aniline derivatives.",

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AU - Takizawa, Shinobu

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Asymmetric oxidative coupling of hydroxycarbazoles: Facile synthesis of (+)-bi-2-hydroxy-3-methylcarbazole

Abstract

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