Asymmetric organolithium additions to imines

Kiyoshi Tomioka, Isao Inoue, Mitsuru Shindo, Kenji Koga

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


The reaction of methyllithium with 4-methoxyphenylimine of 1-naphthalenecarbaldehyde (1) in the presence of the chiral ligand A afforded, contrary to 1,4-addition with the cyclohexylimine, the corresponding 1,2-addition product as an optically active amine (2) in 70% ee.

Original languageEnglish
Pages (from-to)6681-6684
Number of pages4
JournalTetrahedron Letters
Issue number46
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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