TY - JOUR
T1 - Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women
T2 - The Japan Multi-Institutional Collaborative Cohort Study
AU - Matsunaga, Takashi
AU - Kadomatsu, Yuka
AU - Tsukamoto, Mineko
AU - Kubo, Yoko
AU - Okada, Rieko
AU - Nagayoshi, Mako
AU - Tamura, Takashi
AU - Hishida, Asahi
AU - Takezaki, Toshiro
AU - Shimoshikiryo, Ippei
AU - Suzuki, Sadao
AU - Nakagawa, Hiroko
AU - Takashima, Naoyuki
AU - Saito, Yoshino
AU - Kuriki, Kiyonori
AU - Arisawa, Kokichi
AU - Katsuura-Kamano, Sakurako
AU - Kuriyama, Nagato
AU - Matsui, Daisuke
AU - Mikami, Haruo
AU - Nakamura, Yohko
AU - Oze, Isao
AU - Ito, Hidemi
AU - Murata, Masayuki
AU - Ikezaki, Hiroaki
AU - Nishida, Yuichiro
AU - Shimanoe, Chisato
AU - Takeuchi, Kenji
AU - Wakai, Kenji
N1 - Publisher Copyright:
© 2022 Matsunaga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/1
Y1 - 2022/1
N2 - Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.
AB - Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.
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U2 - 10.1371/journal.pone.0262252
DO - 10.1371/journal.pone.0262252
M3 - Article
C2 - 35045125
AN - SCOPUS:85123652576
SN - 1932-6203
VL - 17
JO - PloS one
JF - PloS one
IS - 1 January
M1 - e2662252
ER -
