Abstract
We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
| Original language | English |
|---|---|
| Pages (from-to) | 297-304 |
| Number of pages | 8 |
| Journal | Clinical and Experimental Hypertension |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2012 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Physiology
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In: Clinical and Experimental Hypertension, Vol. 34, No. 4, 01.07.2012, p. 297-304.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Associations between day-by-day variability in blood pressure measured at home and antihypertensive drugs
T2 - The J-HOME-morning study home
AU - Ishikura, Kazuki
AU - Obara, Taku
AU - Kato, Tetsuo
AU - Kikuya, Masahiro
AU - Shibamiya, Taku
AU - Shinki, Takahiro
AU - Ikeda, Urara
AU - Kobayashi, Yuka
AU - Metoki, Hirohito
AU - Mano, Nariyasu
AU - Kuriyama, Shinichi
AU - Ohkubo, Takayoshi
AU - Imai, Yutaka
AU - Yoshida, Makoto
AU - Aoki, S.
AU - Ido, H.
AU - Ito, K.
AU - Kikuchi, K.
AU - Maeda, I.
AU - Mito, T.
AU - Nunokawa, A.
AU - Oda, K.
AU - Suzuki, N.
AU - Takagawa, Y.
AU - Tateda, K.
AU - Tateda, S.
AU - Akimot, M.
AU - Tashima, G.
AU - Fujii, Y.
AU - Onodera, G.
AU - Onodera, T.
AU - Sugiuchi, N.
AU - Suzuki, Y.
AU - Domon, R.
AU - Hayashi, T.
AU - Ishibashi, K.
AU - Ito, K.
AU - Kataoka, S.
AU - Kyogoku, S.
AU - Mashiko, H.
AU - Matsuo, K.
AU - Metoki, H.
AU - Otake, Y.
AU - Saito, J.
AU - Shishido, Y.
AU - Takayama, A.
AU - Tanno, Y.
AU - Toyota, S.
AU - Uchida, N.
AU - Yambe, M.
N1 - Funding Information: This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology, by Junkanki-Byou-Itaku-Kenkyuhi (H19-Kou-8) from the National Cardiovascular Center, and by funding from Nouvelle Place Inc., Japan. The investigators designed and conducted the study and interpreted the findings independently of the sponsors. This study was based on data collected by the J-HOME-Morning study group. Members of the J-HOME-Morning study group Principal Investigator: Yutaka Imai Management Committee: Takayoshi Ohkubo, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai Coordinating and Data Management Center: Taku Obara, Tetsuo Kato, Taku Shibamiya, Takahiro Shinki, Urara Ikeda, Yuka Kobayashi, Makoto Yoshida, Kazuki Ishikura, Masahiro Kikuya Participating Practitioners: [Hokkaido] S. Aoki, H. Ido, K. Ito, K. Kikuchi, I. Maeda, T. Mito, A. Nunokawa, K. Oda, N. Suzuki, Y. Takagawa, K. Tateda, S. Tateda. [Aomori] M. Akimot, G. Tashima. [Iwate] Y. Fujii, G. Onodera, T. Onodera, N. Sugiuchi, Y. Suzuki. [Miyagi] R. Domon, T. Hayashi, K. Ishibashi, K. Ito, S. Kataoka, S. Kyogoku, H. Mashiko, K. Matsuo, H. Metoki, Y. Otake, J. Saito, Y. Shishido, A. Takayama, Y. Tanno, S. Toyota, N. Uchida, M. Yambe. [Akita] M. Fujioka, Y. Kimura, H. Matsuoka, K. Sasaki, M. Wada, H. Yamamoto. [Yamagata] T. Goto, Y. Kamimura, H. Kitamura, Y. Matsuura, Y. Nakayama. [Fukushima]F. Araki,Y. Miyazaki, T. Sakata,H.Sakuma, T. Sato, K. Shimizu, M. Yoshida. [Ibaraki] Y. Deguchi, T. Kano, A. Nishiyama, I. Shinotsuka. [Tochigi] T. Kobayashi, S. Kumakura, T. Masuda, T. Watanabe. [Gunma] T. Honzawa, H. Kubo. [Saitama] H. Aoki, S. Kanozawa, H. Koide, K. Nishiyama, K. Sakamoto, J. Suda, T. Tagaya, A. Yamada, K. Yamanaka. [Chiba] R. Hasegawa, S. Hirai, K. Horibe, A. Jujo, M. Suzuki, N. Tamiya, T. Ueda, T. Umimura. [Tokyo] N. Aoki, S. Arai, T. Himeno, T. Ikeda, H. Inoue, Y. Itagaki, F. Kamata, M. Kamegai, M. Kato, S. Kijima, F. Kotou, T. Kurokawa, H. Kurumatani, K. Minagawa, T. Miura, Y. Miyoshi, T. Morikawa, T. Morita, M. Nago, H. Nakada, H. Nakagawa, J. Nakamura, A. Niwa, E. Osuga, H. Ozaki, A. Sasaki, H. Sugahara, K. Suzuki, H. Tamura, H. Tomonari, M. Yamada. [Kanagawa] H. Kikuchi, T. Mikawa, K. Minamisawa, M. Miyakawa, M. Nishimura, T. Shinkai, M. Ushiyama, H. Yamamoto, S. Yokoyama. [Yamanashi] A. Horiuchi, M. Nagasaka. [Nagano] M. Fujita, N. Hoshiyama, M. Ikeda, A. Sakairi, T. Shinozaki, H. Takaki, K. Uchiba, H. Yanagisawa. [Niigata] S. Kobayashi, K. Sasaki, M. Takahashi, S. Takahashi. [Ishikawa] K. Doniwa, H. Higashi, N. Ohya, M. Yasuhara. [Fukui] S. Saiki. [Gifu] H. Ando, M. Fujii, K. Miyoshi. [Shizuoka] K. Fuchimoto, M. Kogure, K. Sugiura, T. Suzuki, N. Takahashi, Y. Takahira. [Aichi] N. Adachi, Y. Koyama, Y. Miyazaki, S. Nakamura, G. Narita, O. Nojiri, Y. Okamoto, K. Sakakura, M. Takasawa, T. Takenaka, H. Tatematsu, T. Uno, Y. Watanabe. [Mie] N. Ishida, U. Kano, N. Morita, H. Okano, T. Takahashi. [Shiga] O. Yamaoka. [Kyoto] H. Hayashi, O. Kuroda, Y. Matsushita, T. Mizuno, Y. Taniguchi, M. Yamashita. [Osaka] S. Arai, Y. Fujimura, S. Fujita, T. Hakuto, Y. Ikuno, H. Ishida, R. Kondo, K. Masaki, M. Miyataka, K. Nao, A. Numata, S. Saeki, H. Sakamoto, K. Suyama, K. Takada, T. Takenaka, K. Teramoto, G. Ueda, N. Wakaki, T. Yokotani. [Hyogo] N. Handa, S. Katsuya, K. Kondo, K. Nagamatsu, K. Nakamura, T. Okano, H. Omori, N. Takahashi, Y. Tsuji, Y. Yanaka, Y. Yonezawa. [Nara] Y. Matsumura, Y. Nakamura, K. Sawada, H. Shimomura, H. Suzuki. [Wakayama] K. Furuta, N. Tamaki, Y. Wanaka. [Shimane] A. Inoue, M. Kamura, N. Yuhara. [Okayama] A. Fushimi, Y. Ido, I. Karai, K. Kurosumi, N. Maeda, T. Nishigaki, Y. Nishihara, T. Shindo, T. Yoshimoto. [Hiroshima] T. Furue, S. Ikeda, K. Kishizuchi, A. Ozawa, J. Ozawa, N. Sasaki, S. Sasaki, N. Shigeto, M. Tanabe, H. Yoshimoto. [Yamaguchi] T. Hirokuni, M. Nakatsuka, T. Noda, M. Tosaka, Y. Toshima, T. Wada, M. Wakimoto, T. Yamanaka. [Tokushima] M. Kimura, A. Ota. [Kagawa] T. Fukui, W. Furumoto, K. Mashima, T. Nakatsu, T. Yokoi. [Kochi] T. Nakayama. [Fukuoka] S. Azakami, T. Eto, Y. Fujishima, Y. Fukudome, S. Goto, H. Hara, Y. Harada, T. Hoashi, K. Imoto, R. Inoue, T. Ishizaki, Y. Ito, T. Ito, T. Jinnochi, A. Kawasaki, S. Miake, J. Miyagi, K. Nagasawa, K. Okada, T. Okita, T. Otonari, Y. Tachikawa, K. Takaki, S. Tanaka, H. Urata, S. Yoshioka. [Saga] H. Ikeda, R. Kaihara, T. Kuwahara, I. Matsuo, O. Nagata, H. Saito, R. Shindo, Y. Takeoka. [Nagasaki] A. Ito, S. Kusano, M. Tokunaga. [Kumamoto] S. Hamasaki, Y. Honda, K. Iwai, K. Izuno, K. Koyama, H. Maeda, A. Maki, F. Semba, S. Yi. [Oita] H. K, K. Ninomiya. [Miyazaki] Y. Endo, Y. Ezaki, R. Narita. [Kagoshima] I. Hatashida, S. Komaki, R. Kuroiwa, H. Yoshii. [Okinawa] Y. Nakamura.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
AB - We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
UR - http://www.scopus.com/inward/record.url?scp=84862211455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862211455&partnerID=8YFLogxK
U2 - 10.3109/10641963.2012.681087
DO - 10.3109/10641963.2012.681087
M3 - Article
C2 - 22564087
AN - SCOPUS:84862211455
SN - 1064-1963
VL - 34
SP - 297
EP - 304
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 4
ER -