TY - JOUR
T1 - Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma
T2 - Positive association of a T924C polymorphism in the thromboxane A2 receptor gene
AU - Unoki, Motoko
AU - Furuta, Sachiyo
AU - Onouchi, Yoshihiro
AU - Watanabe, Otsu
AU - Doi, Satoru
AU - Fujiwara, Hiroshi
AU - Miyatake, Akihiko
AU - Fujita, Kimie
AU - Tamari, Mayumi
AU - Nakamura, Yusuke
N1 - Funding Information:
Acknowledgements We thank Rie Hayashi for her technical help. This work was supported in part by a „Research for the Future“ Program Grant (96L00102) of the Japan Society for the Promotion of Science.
PY - 2000
Y1 - 2000
N2 - Although intensive studies have attempted to elucidate the genetic background of bronchial asthma (BA), one of the most common of the chronic inflammatory diseases in human populations, genetic factors associated with its pathogenesis are still not well understood. We surveyed 29 possible candidate genes for this disease for single nucleotide polymorphisms (SNPs), the most frequent type of genetic variation, in genomic DNAs from Japanese BA patients. We identified 33 SNPs, only four of which had been reported previously, among 14 of those genes. We also performed association studies using 585 BA patients and 343 normal controls for these SNPs. Of the 33 SNPs tested, 32 revealed no positive association with BA, but a T924C polymorphism in the thromboxane A2 receptor gene showed significant association (χ2 = 4.71, P = 0.030), especially with respect to adult patients (χ2 = 6.20, P = 0.013). Our results suggest that variants of the TBXA2R gene or some nearby gene(s) may play an important role in the pathogenesis of adult BA.
AB - Although intensive studies have attempted to elucidate the genetic background of bronchial asthma (BA), one of the most common of the chronic inflammatory diseases in human populations, genetic factors associated with its pathogenesis are still not well understood. We surveyed 29 possible candidate genes for this disease for single nucleotide polymorphisms (SNPs), the most frequent type of genetic variation, in genomic DNAs from Japanese BA patients. We identified 33 SNPs, only four of which had been reported previously, among 14 of those genes. We also performed association studies using 585 BA patients and 343 normal controls for these SNPs. Of the 33 SNPs tested, 32 revealed no positive association with BA, but a T924C polymorphism in the thromboxane A2 receptor gene showed significant association (χ2 = 4.71, P = 0.030), especially with respect to adult patients (χ2 = 6.20, P = 0.013). Our results suggest that variants of the TBXA2R gene or some nearby gene(s) may play an important role in the pathogenesis of adult BA.
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U2 - 10.1007/s004390000267
DO - 10.1007/s004390000267
M3 - Article
C2 - 10830912
AN - SCOPUS:0034013702
SN - 0340-6717
VL - 106
SP - 440
EP - 446
JO - Human Genetics
JF - Human Genetics
IS - 4
ER -
