Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

Yusuke Akiyama; Shunsuke Katsuki; Tetsuya Matoba; Yasuhiro Nakano; Susumu Takase; Soichi Nakashiro; Mitsutaka Yamamoto; Yasushi Mukai; Shuujirou Inoue; Keiji Oi; Taiki Higo; Masao Takemoto; Nobuhiro Suematsu; Kenichi Eshima; Kenji Miyata; Makoto Usui; Kenji Sadamatsu; Toshiaki Kadokami; Kiyoshi Hironaga; Ikuyo Ichi; Koji Todaka; Junji Kishimoto; Hiroyuki Tsutsui

doi:10.3390/nu15132997

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shuujirou Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo IchiKoji Todaka, Junji Kishimoto, Hiroyuki Tsutsui

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Abstract

Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis”. Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.

Original language	English
Article number	2997
Journal	Nutrients
Volume	15
Issue number	13
DOIs	https://doi.org/10.3390/nu15132997
Publication status	Published - Jul 2023

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Food Science
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Akiyama, Y., Katsuki, S., Matoba, T., Nakano, Y., Takase, S., Nakashiro, S., Yamamoto, M., Mukai, Y., Inoue, S., Oi, K., Higo, T., Takemoto, M., Suematsu, N., Eshima, K., Miyata, K., Usui, M., Sadamatsu, K., Kadokami, T., Hironaga, K., ... Tsutsui, H. (2023). Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis. Nutrients, 15(13), Article 2997. https://doi.org/10.3390/nu15132997

Akiyama, Y, Katsuki, S , Matoba, T , Nakano, Y , Takase, S, Nakashiro, S, Yamamoto, M, Mukai, Y, Inoue, S, Oi, K, Higo, T, Takemoto, M, Suematsu, N, Eshima, K, Miyata, K, Usui, M, Sadamatsu, K, Kadokami, T, Hironaga, K, Ichi, I, Todaka, K , Kishimoto, J & Tsutsui, H 2023, 'Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis', Nutrients, vol. 15, no. 13, 2997. https://doi.org/10.3390/nu15132997

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title = "Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis",

abstract = "Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis”. Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.",

author = "Yusuke Akiyama and Shunsuke Katsuki and Tetsuya Matoba and Yasuhiro Nakano and Susumu Takase and Soichi Nakashiro and Mitsutaka Yamamoto and Yasushi Mukai and Shuujirou Inoue and Keiji Oi and Taiki Higo and Masao Takemoto and Nobuhiro Suematsu and Kenichi Eshima and Kenji Miyata and Makoto Usui and Kenji Sadamatsu and Toshiaki Kadokami and Kiyoshi Hironaga and Ikuyo Ichi and Koji Todaka and Junji Kishimoto and Hiroyuki Tsutsui",

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year = "2023",

month = jul,

doi = "10.3390/nu15132997",

language = "English",

volume = "15",

journal = "Nutrients",

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T1 - Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease

T2 - A Covariance Structure Analysis

AU - Akiyama, Yusuke

AU - Katsuki, Shunsuke

AU - Matoba, Tetsuya

AU - Nakano, Yasuhiro

AU - Takase, Susumu

AU - Nakashiro, Soichi

AU - Yamamoto, Mitsutaka

AU - Mukai, Yasushi

AU - Inoue, Shuujirou

AU - Oi, Keiji

AU - Higo, Taiki

AU - Takemoto, Masao

AU - Suematsu, Nobuhiro

AU - Eshima, Kenichi

AU - Miyata, Kenji

AU - Usui, Makoto

AU - Sadamatsu, Kenji

AU - Kadokami, Toshiaki

AU - Hironaga, Kiyoshi

AU - Ichi, Ikuyo

AU - Todaka, Koji

AU - Kishimoto, Junji

AU - Tsutsui, Hiroyuki

PY - 2023/7

Y1 - 2023/7

N2 - Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis”. Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.

AB - Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis”. Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.

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JO - Nutrients

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Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

Abstract

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