TY - JOUR
T1 - Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan
AU - on behalf of the Neonatal Research Network of Japan (NRNJ)
AU - Matsushita, Yuki
AU - Sakai, Yasunari
AU - Torio, Michiko
AU - Inoue, Hirosuke
AU - Ochiai, Masayuki
AU - Yasuoka, Kazuaki
AU - Kurata, Hiroaki
AU - Fujiyoshi, Junko
AU - Ichiyama, Masako
AU - Taguchi, Tomoaki
AU - Kato, Kiyoko
AU - Ohga, Shouichi
N1 - Funding Information:
Funding This study was supported in part by JSPS KAKEN Grant Number JP17K16268 (YM), JP17K16301 (MT), JP17K16300 (HI) and JP16K19688 (JF).
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: To determine clinical features of very low birth weight infants (VLBWIs) who had developed epilepsy by age 3 years. Study design: Multicenter cohort study using the Neonatal Research Network of Japan database. We analyzed clinical variables of 8431 VLBWIs who had recorded data of neurological sequelae at age 3 years. Logistic regression identified the association between variables and development of epilepsy. Result: One hundred and forty-three (1.7%) infants developed epilepsy, 683 (8.1%) showed cerebral palsy (CP), and 1114 (13.2%) had psychomotor delay. Epilepsy was associated with history of sepsis [adjusted odds ratio (AOR) 3.23], severe intraventricular hemorrhage (IVH; AOR 5.13), and cystic periventricular leukomalacia (PVL; AOR 12.7). Severe IVH and cystic PVL were also frequently associated with CP and psychomotor delay. Conclusion: Severe IVH and cystic PVL are strongly associated with development of epilepsy, as well as other neurological sequelae, and are potential critical therapeutic targets.
AB - Objective: To determine clinical features of very low birth weight infants (VLBWIs) who had developed epilepsy by age 3 years. Study design: Multicenter cohort study using the Neonatal Research Network of Japan database. We analyzed clinical variables of 8431 VLBWIs who had recorded data of neurological sequelae at age 3 years. Logistic regression identified the association between variables and development of epilepsy. Result: One hundred and forty-three (1.7%) infants developed epilepsy, 683 (8.1%) showed cerebral palsy (CP), and 1114 (13.2%) had psychomotor delay. Epilepsy was associated with history of sepsis [adjusted odds ratio (AOR) 3.23], severe intraventricular hemorrhage (IVH; AOR 5.13), and cystic periventricular leukomalacia (PVL; AOR 12.7). Severe IVH and cystic PVL were also frequently associated with CP and psychomotor delay. Conclusion: Severe IVH and cystic PVL are strongly associated with development of epilepsy, as well as other neurological sequelae, and are potential critical therapeutic targets.
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U2 - 10.1038/s41372-019-0494-7
DO - 10.1038/s41372-019-0494-7
M3 - Article
C2 - 31527650
AN - SCOPUS:85073816067
SN - 0743-8346
VL - 39
SP - 1472
EP - 1479
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -