Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women

Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida, Takuma Furukawa, Chiharu Iwasaka, Keitaro Tanaka, Jun Otonari, Hiroaki Ikezaki, Yoko Kubo, Yasufumi Kato, Takashi Tamura, Asahi Hishida, Keitaro Matsuo, Hidemi Ito, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao SuzukiMiki Watanabe, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.

Original languageEnglish
Article number291
JournalScientific reports
Issue number1
Publication statusPublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women'. Together they form a unique fingerprint.

Cite this