TY - JOUR
T1 - Association of anthropometry and weight change with risk of dementia and its major subtypes
T2 - A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
AU - Lee, Crystal Man Ying
AU - Woodward, Mark
AU - Batty, G. David
AU - Beiser, Alexa S.
AU - Bell, Steven
AU - Berr, Claudine
AU - Bjertness, Espen
AU - Chalmers, John
AU - Clarke, Robert
AU - Dartigues, Jean Francois
AU - Davis-Plourde, Kendra
AU - Debette, Stéphanie
AU - Di Angelantonio, Emanuele
AU - Feart, Catherine
AU - Frikke-Schmidt, Ruth
AU - Gregson, John
AU - Haan, Mary N.
AU - Hassing, Linda B.
AU - Hayden, Kathleen M.
AU - Hoevenaar-Blom, Marieke P.
AU - Kaprio, Jaakko
AU - Kivimaki, Mika
AU - Lappas, Georgios
AU - Larson, Eric B.
AU - LeBlanc, Erin S.
AU - Lee, Anne
AU - Lui, Li Yung
AU - Moll van Charante, Eric P.
AU - Ninomiya, Toshiharu
AU - Nordestgaard, Liv Tybjærg
AU - Ohara, Tomoyuki
AU - Ohkuma, Toshiaki
AU - Palviainen, Teemu
AU - Peres, Karine
AU - Peters, Ruth
AU - Qizilbash, Nawab
AU - Richard, Edo
AU - Rosengren, Annika
AU - Seshadri, Sudha
AU - Shipley, Martin
AU - Singh-Manoux, Archana
AU - Strand, Bjorn Heine
AU - van Gool, Willem A.
AU - Vuoksimaa, Eero
AU - Yaffe, Kristine
AU - Huxley, Rachel R.
N1 - Funding Information:
MW has received personal fees from Amgen and Kirin outside the submitted work; JC has received grants from Idorsia outside the submitted work; EDA has received grants from NHS Blood and Transplant, British Heart Foundation, UK Medical Research Council, and National Institute for Health Research outside the submitted work; JK has received grants from Academy of Finland during the conduct of the study; MK has received grants from the Medical Research Council (MR/R024227/1), NIH National Institute on Aging (R01AG056477), Academy of Finland (311492), and Helsinki Institute of Life Sciences during the conduct of the study; EBL has received grants from NIH during the conduct of the study and personal fees from Up to Date outside the submitted work; ESL reported grants from Merck Inc outside the submitted work; NQ reported other from pharmaceutical industry outside the submitted work; EV reported grants from The Academy of Finland during the conduct of the study; KY serves on DSMBs for Takeda and Eli Lily outside the submitted work and is a member of the Beeson Scholars in Aging Scientific Advisory Board and of the Senate of the German Center for Neurodegenerative Diseases.
Funding Information:
Adult Changes in Thought Study was funded by a National Institutes of Health Grant U01 AG0006781. The Cache County Memory Study was funded by NIA Grants R01 AG011380 and R01 AG018712; Dr Hayden's effort on this project was supported by NIA R01 AG042633. J. Kaprio acknowledges support for the Finnish Twin Cohort by the Academy of Finland (Grants 265240, 263278, 308248, and 312073). This work was supported by the dedication of the Framingham Heart Study participants. This work and the investigators received grant support from the National Heart, Lung, and Blood Institute's Framingham Heart Study (contracts no. N01-HC-25195 and HHSN268201500001I) and grants from the National Institute of Neurological Disorders and Stroke (NS17950 and UH2 NS100605), and the National Institute on Aging (R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, and U01 AG052409). The Study of Osteoporotic Fractures (SOF) is supported by National Institutes of Health funding. The National Institute on Aging (NIA) provides support under the following grant numbers: R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, and R01 AG027576. The Three-City Study is conducted under a partnership agreement between the INSERM, the ISPED of the University of Bordeaux, and Sanofi-Aventis. The Foundation pour la Recherche M?dicale funded the preparation and initiation of the study. TheThree-City Study is also supported by the Caisse Nationale Maladie des Travailleurs Salari?s, Direction G?n?rale de la Sant?, Mutuelle G?n?rale de l'Education Nationale, Institut de la Long?vit?, Conseils R?gionaux of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research-INSERM Programme ? Cohortes et collections de donn?es biologiques ?, French National Research Agency COGINUT ANR-06-PNRA-005, COGICARE ANR Longvie (LVIE-003-01), the Fondation Plan Alzheimer (FCS 2009-2012), and the Caisse Nationale pour la Solidarit? et l'Autonomie. This research has been conducted using the UK Biobank Resource under Application number 7439. SBell and EDA are supported by core funding from NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (RG/13/13/30194), and the NIHR Cambridge BRC. GDB is supported by the UK Medical Research Council (MR/P023444/1) and the US National Institute on Aging (1R56AG052519-01; 1R01AG052519-01A1). Whitehall II was supported by the Medical Research Council (MR/R024227/1), the NIH National Institute on Aging (R01AG056477), and British Heart Foundation (32334). EVuoksimaa was supported by the Academy of Finland (Grants 314639 and 320109)
Funding Information:
Adult Changes in Thought Study was funded by a National Institutes of Health Grant U01 AG0006781. The Cache County Memory Study was funded by NIA Grants R01 AG011380 and R01 AG018712; Dr Hayden's effort on this project was supported by NIA R01 AG042633. J. Kaprio acknowledges support for the Finnish Twin Cohort by the Academy of Finland (Grants 265240, 263278, 308248, and 312073). This work was supported by the dedication of the Framingham Heart Study participants. This work and the investigators received grant support from the National Heart, Lung, and Blood Institute's Framingham Heart Study (contracts no. N01‐HC‐25195 and HHSN268201500001I) and grants from the National Institute of Neurological Disorders and Stroke (NS17950 and UH2 NS100605), and the National Institute on Aging (R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, and U01 AG052409). The Study of Osteoporotic Fractures (SOF) is supported by National Institutes of Health funding. The National Institute on Aging (NIA) provides support under the following grant numbers: R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, and R01 AG027576. The Three‐City Study is conducted under a partnership agreement between the INSERM, the ISPED of the University of Bordeaux, and Sanofi‐Aventis. The Foundation pour la Recherche Médicale funded the preparation and initiation of the study. TheThree‐City Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Mutuelle Générale de l'Education Nationale, Institut de la Longévité, Conseils Régionaux of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research‐INSERM Programme « Cohortes et collections de données biologiques », French National Research Agency COGINUT ANR‐06‐PNRA‐005, COGICARE ANR Longvie (LVIE‐003‐01), the Fondation Plan Alzheimer (FCS 2009‐2012), and the Caisse Nationale pour la Solidarité et l'Autonomie. This research has been conducted using the UK Biobank Resource under Application number 7439. SBell and EDA are supported by core funding from NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU‐2014‐10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (RG/13/13/30194), and the NIHR Cambridge BRC. GDB is supported by the UK Medical Research Council (MR/P023444/1) and the US National Institute on Aging (1R56AG052519‐01; 1R01AG052519‐01A1). Whitehall II was supported by the Medical Research Council (MR/R024227/1), the NIH National Institute on Aging (R01AG056477), and British Heart Foundation (32334). EVuoksimaa was supported by the Academy of Finland (Grants 314639 and 320109)
Publisher Copyright:
© 2020 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index–defined lower-normal weight (18.5-22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
AB - Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index–defined lower-normal weight (18.5-22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
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U2 - 10.1111/obr.12989
DO - 10.1111/obr.12989
M3 - Review article
C2 - 31898862
AN - SCOPUS:85077848803
SN - 1467-7881
VL - 21
JO - Obesity Reviews
JF - Obesity Reviews
IS - 4
M1 - e12989
ER -
