Association between variants of mast cell chymase gene and serum IgE levels in eczema

X. Q. Mao; T. Shirakawa; T. Enomoto; S. Shimazu; Y. Dake; H. Kitano; A. Hagihara; J. M. Hopkin

doi:10.1159/000022782

Association between variants of mast cell chymase gene and serum IgE levels in eczema

X. Q. Mao, T. Shirakawa, T. Enomoto, S. Shimazu, Y. Dake, H. Kitano, A. Hagihara, J. M. Hopkin

Health Care Administration and Management

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

Original language	English
Pages (from-to)	38-41
Number of pages	4
Journal	Human Heredity
Volume	48
Issue number	1
DOIs	https://doi.org/10.1159/000022782
Publication status	Published - Jan 1 1998

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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AU - Shimazu, S.

AU - Dake, Y.

AU - Kitano, H.

AU - Hagihara, A.

AU - Hopkin, J. M.

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AB - 851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

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Association between variants of mast cell chymase gene and serum IgE levels in eczema

Abstract

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