TY - JOUR
T1 - Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia
AU - Onitsuka, Toshiaki
AU - Nestor, Paul G.
AU - Gurrera, Ronald J.
AU - Shenton, Martha E.
AU - Kasai, Kiyoto
AU - Frumin, Melissa
AU - Niznikiewicz, Margaret A.
AU - McCarley, Robert W.
PY - 2005/3
Y1 - 2005/3
N2 - Objective: The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia. Method: Male patients (N=24) and age-matched male comparison subjects (N=26) completed NEO Five-Factor Inventory personality measures of extraversion and underwent high-spatial-resolution magnetic resonance imaging of anterior and posterior fusiform gyrus gray matter. Results: Low extraversion scores were significantly correlated with gray matter volume reductions in the right posterior fusiform gyrus for patients but not comparison subjects. Conclusions: Reduced right posterior fusiform gyrus volume may contribute to disease-related social disturbances, characterized by both low extraversion and reduced sensitivity to human faces.
AB - Objective: The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia. Method: Male patients (N=24) and age-matched male comparison subjects (N=26) completed NEO Five-Factor Inventory personality measures of extraversion and underwent high-spatial-resolution magnetic resonance imaging of anterior and posterior fusiform gyrus gray matter. Results: Low extraversion scores were significantly correlated with gray matter volume reductions in the right posterior fusiform gyrus for patients but not comparison subjects. Conclusions: Reduced right posterior fusiform gyrus volume may contribute to disease-related social disturbances, characterized by both low extraversion and reduced sensitivity to human faces.
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U2 - 10.1176/appi.ajp.162.3.599
DO - 10.1176/appi.ajp.162.3.599
M3 - Article
C2 - 15741479
AN - SCOPUS:14844291417
SN - 0002-953X
VL - 162
SP - 599
EP - 601
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 3
ER -
