TY - JOUR
T1 - Association between oxytocin receptor gene rs53576 polymorphism and behavioral inhibition/activation system (BIS/BAS) sensitivity
AU - Choi, Damee
AU - Tsuji, Haruna
AU - Watanuki, Shigeki
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP15F15013 .
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/1/15
Y1 - 2018/1/15
N2 - Oxytocin influences a wide range of human behaviors. Previous studies have suggested that these effects of oxytocin on human behavior are based on association with approach/withdrawal behavior. To test this hypothesis, we investigated whether the oxytocin receptor gene (OXTR) rs53576 polymorphism affects behavioral inhibition/activation system (BIS/BAS) sensitivity in healthy university students (n = 290). Our results show a significant allele-load-dependent increase by the G allele of OXTR rs53576 in BAS score, supporting previous findings that oxytocin increases approach-related behavior. Meanwhile, BIS score did not show a significant allele-load-dependent effect of OXTR rs53576, and association between oxytocin and withdrawal-related behavior is not suggested from the present study. Since the effect of OXTR rs53576 polymorphism on BAS sensitivity in the present study was relatively small, replication in a larger sample is needed to confirm this finding.
AB - Oxytocin influences a wide range of human behaviors. Previous studies have suggested that these effects of oxytocin on human behavior are based on association with approach/withdrawal behavior. To test this hypothesis, we investigated whether the oxytocin receptor gene (OXTR) rs53576 polymorphism affects behavioral inhibition/activation system (BIS/BAS) sensitivity in healthy university students (n = 290). Our results show a significant allele-load-dependent increase by the G allele of OXTR rs53576 in BAS score, supporting previous findings that oxytocin increases approach-related behavior. Meanwhile, BIS score did not show a significant allele-load-dependent effect of OXTR rs53576, and association between oxytocin and withdrawal-related behavior is not suggested from the present study. Since the effect of OXTR rs53576 polymorphism on BAS sensitivity in the present study was relatively small, replication in a larger sample is needed to confirm this finding.
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U2 - 10.1016/j.paid.2017.09.001
DO - 10.1016/j.paid.2017.09.001
M3 - Article
AN - SCOPUS:85028972856
SN - 0191-8869
VL - 121
SP - 223
EP - 226
JO - Personality and Individual Differences
JF - Personality and Individual Differences
ER -
