Association between IL-4 genotype and IL-4 production in the Japanese population

H. Nakashima; K. Miyake; Y. Inoue; S. Shimizu; M. Akahoshi; Y. Tanaka; T. Otsuka; M. Harada

doi:10.1038/sj.gene.6363830

Association between IL-4 genotype and IL-4 production in the Japanese population

H. Nakashima, K. Miyake, Y. Inoue, S. Shimizu, M. Akahoshi, Y. Tanaka, T. Otsuka, M. Harada

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130 Citations (Scopus)

Abstract

We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	Genes and Immunity
Volume	3
Issue number	2
DOIs	https://doi.org/10.1038/sj.gene.6363830
Publication status	Published - Apr 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology
Genetics
Genetics(clinical)

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10.1038/sj.gene.6363830

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title = "Association between IL-4 genotype and IL-4 production in the Japanese population",

abstract = "We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.",

author = "H. Nakashima and K. Miyake and Y. Inoue and S. Shimizu and M. Akahoshi and Y. Tanaka and T. Otsuka and M. Harada",

note = "Funding Information: This research was supported by Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare. Received 6 September 2001; revised 28 October 2001; accepted 30 October 2001",

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doi = "10.1038/sj.gene.6363830",

language = "English",

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AU - Nakashima, H.

AU - Miyake, K.

AU - Inoue, Y.

AU - Shimizu, S.

AU - Akahoshi, M.

AU - Tanaka, Y.

AU - Otsuka, T.

AU - Harada, M.

N1 - Funding Information: This research was supported by Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare. Received 6 September 2001; revised 28 October 2001; accepted 30 October 2001

PY - 2002/4

Y1 - 2002/4

N2 - We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

AB - We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

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JF - Genes and Immunity

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Association between IL-4 genotype and IL-4 production in the Japanese population

Abstract

All Science Journal Classification (ASJC) codes

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