Association between HLA and Japanese patients with rheumatoid arthritis

Nobuo Ohta; Yoshi K. Nishimura; Kiyoaki Tanimoto; Yoshihiko Horiuchi; Chiyuki Abe; Yuichi Shiokawa; Tohru Abe; Makoto Katagiri; Takashi Yoshiki; Takehiko Sasazuki

doi:10.1016/0198-8859(82)90057-X

Association between HLA and Japanese patients with rheumatoid arthritis

Nobuo Ohta, Yoshi K. Nishimura, Kiyoaki Tanimoto, Yoshihiko Horiuchi, Chiyuki Abe, Yuichi Shiokawa, Tohru Abe, Makoto Katagiri, Takashi Yoshiki, Takehiko Sasazuki

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

Japanese patients with rheumatoid arthritis (RA) were observed to have a statistical association with HLA-DR4, MT3. Strong association between the clinical severity of RA and HLA was also observed. Male patients had a stronger association with HLA than female patients. Males are more resistant to RA than females. This suggested that the threshold of liability for RA is higher in males than in females. Japanese patients with RA with systemic vasculitis were negative for HLA-Bw44 and had antilymphocytotoxic autoantibody, indicating that RA with systemic vasculities is different in etiology from RA without systemic vasculities.

Original language	English
Pages (from-to)	123-132
Number of pages	10
Journal	Human Immunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(82)90057-X
Publication status	Published - Oct 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/0198-8859(82)90057-X

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@article{a646f3ce51064e7f92d1d51219c0ced5,

title = "Association between HLA and Japanese patients with rheumatoid arthritis",

abstract = "Japanese patients with rheumatoid arthritis (RA) were observed to have a statistical association with HLA-DR4, MT3. Strong association between the clinical severity of RA and HLA was also observed. Male patients had a stronger association with HLA than female patients. Males are more resistant to RA than females. This suggested that the threshold of liability for RA is higher in males than in females. Japanese patients with RA with systemic vasculitis were negative for HLA-Bw44 and had antilymphocytotoxic autoantibody, indicating that RA with systemic vasculities is different in etiology from RA without systemic vasculities.",

author = "Nobuo Ohta and Nishimura, {Yoshi K.} and Kiyoaki Tanimoto and Yoshihiko Horiuchi and Chiyuki Abe and Yuichi Shiokawa and Tohru Abe and Makoto Katagiri and Takashi Yoshiki and Takehiko Sasazuki",

note = "Funding Information: ACKNOWLEDGMENT This study was suppor~:ed in part by a Research Grant from the Intractable D/~c~* Division, Public Health Bureau, Ministry of Health and Welfare, Japan ~19{"}~), D~L 1981), and a Grant-in-Aid for developmental Scientific Research 548156, Miai_~D{"} ~4 Education, Japan (19S0, 1981), and a Research Grant (1979) from the Mitsubis\[~i Foundation, Japan.",

year = "1982",

month = oct,

doi = "10.1016/0198-8859(82)90057-X",

language = "English",

volume = "5",

pages = "123--132",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Association between HLA and Japanese patients with rheumatoid arthritis

AU - Ohta, Nobuo

AU - Nishimura, Yoshi K.

AU - Tanimoto, Kiyoaki

AU - Horiuchi, Yoshihiko

AU - Abe, Chiyuki

AU - Shiokawa, Yuichi

AU - Abe, Tohru

AU - Katagiri, Makoto

AU - Yoshiki, Takashi

AU - Sasazuki, Takehiko

N1 - Funding Information: ACKNOWLEDGMENT This study was suppor~:ed in part by a Research Grant from the Intractable D/~c~* Division, Public Health Bureau, Ministry of Health and Welfare, Japan ~19"~), D~L 1981), and a Grant-in-Aid for developmental Scientific Research 548156, Miai_~D" ~4 Education, Japan (19S0, 1981), and a Research Grant (1979) from the Mitsubis\[~i Foundation, Japan.

PY - 1982/10

Y1 - 1982/10

N2 - Japanese patients with rheumatoid arthritis (RA) were observed to have a statistical association with HLA-DR4, MT3. Strong association between the clinical severity of RA and HLA was also observed. Male patients had a stronger association with HLA than female patients. Males are more resistant to RA than females. This suggested that the threshold of liability for RA is higher in males than in females. Japanese patients with RA with systemic vasculitis were negative for HLA-Bw44 and had antilymphocytotoxic autoantibody, indicating that RA with systemic vasculities is different in etiology from RA without systemic vasculities.

AB - Japanese patients with rheumatoid arthritis (RA) were observed to have a statistical association with HLA-DR4, MT3. Strong association between the clinical severity of RA and HLA was also observed. Male patients had a stronger association with HLA than female patients. Males are more resistant to RA than females. This suggested that the threshold of liability for RA is higher in males than in females. Japanese patients with RA with systemic vasculitis were negative for HLA-Bw44 and had antilymphocytotoxic autoantibody, indicating that RA with systemic vasculities is different in etiology from RA without systemic vasculities.

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U2 - 10.1016/0198-8859(82)90057-X

DO - 10.1016/0198-8859(82)90057-X

M3 - Article

C2 - 6815137

AN - SCOPUS:0020407486

SN - 0198-8859

VL - 5

SP - 123

EP - 132

JO - Human Immunology

JF - Human Immunology

IS - 2

ER -

Association between HLA and Japanese patients with rheumatoid arthritis

Abstract

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