TY - JOUR
T1 - Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects
AU - Ono, Yutaka
AU - Manki, Hiroshi
AU - Yoshimura, Kimio
AU - Muramatsu, Taro
AU - Mizushima, Hiroko
AU - Higuchi, Susumu
AU - Yagi, Gohei
AU - Kanba, Shigenobu
AU - Asai, Masahiro
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Japanese version of Cloninger's Temperament and Character Inventory. The Novelty Seeking subscale of Exploratory Excitability had a significant association with long alleles of the polymorphic exon III repeat sequence of D4DR. Our results suggest that there is an association between long alleles of the polymorphic exon III repeat sequence of D4DR and the personality traits of the Novelty Seeking subscale of Exploratory Excitability, regardless of racial differences in the frequencies of D4DR exon III repeat polymorphism.
AB - This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Japanese version of Cloninger's Temperament and Character Inventory. The Novelty Seeking subscale of Exploratory Excitability had a significant association with long alleles of the polymorphic exon III repeat sequence of D4DR. Our results suggest that there is an association between long alleles of the polymorphic exon III repeat sequence of D4DR and the personality traits of the Novelty Seeking subscale of Exploratory Excitability, regardless of racial differences in the frequencies of D4DR exon III repeat polymorphism.
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U2 - 10.1002/(SICI)1096-8628(19970919)74:5<501::AID-AJMG9>3.0.CO;2-Q
DO - 10.1002/(SICI)1096-8628(19970919)74:5<501::AID-AJMG9>3.0.CO;2-Q
M3 - Article
C2 - 9342200
AN - SCOPUS:0030796344
SN - 1552-4841
VL - 74
SP - 501
EP - 503
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 5
ER -
