Associated anomalies in congenital diaphragmatic hernia: Perinatal characteristics and impact on postnatal survival

Nobuhiro Hidaka, Keisuke Ishii, Aki Mabuchi, Akiko Yamashita, Shiyo Ota, Jun Sasahara, Masaharu Murata, Nobuaki Mitsuda

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective: We aimed to investigate the clinical characteristics and postnatal outcomes of fetuses with congenital diaphragmatic hernia (CDH) and additional anomalies. Materials and methods: We reviewed the charts of fetuses with CDH managed between 2005 and 2013. Patients were divided into complex and isolated groups based on the presence of additional anomalies. We analyzed the respective polyhydramnios, liver herniation, stomach position, lung to thorax transverse area ratio (LTR), and prognoses of the two groups. The survival rates of both groups were assessed based on the LTR as well as on stomach and liver positions. Results: CDH was diagnosed in 65 fetuses, and additional anomalies were found in 23. The incidences of liver herniation, polyhydramnios, and death were significantly higher, and LTR was significantly lower, in the complex group. The mortality rate of fetuses with a LTR < 0.08 was lower than that of fetuses with a LTR of. 0.08 in the complex group. Further, the survival rate of fetuses with intrathoracic liver was lower than those without liver herniation. Conclusions: The prognosis of complex CDH is poor. This may result from both the associated anomalies and the severity of CDH itself. Even in complex CDHs, intrathoracic liver and LTR values are useful in estimating postnatal outcome.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalJournal of Perinatal Medicine
Issue number2
Publication statusPublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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