Arterial spin-labelin magnetic resonance imaging: The timing of regional maximal perfusion-related signal intensity revealed by a multiphase technique

Tomoyuki Noguchi, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Eiki Nagao, Hiroshi Honda

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    5 Citations (Scopus)

    Abstract

    Purpose We investigated the time interval from labeling to peak (TLP) of perfusion-signal intensity (SIs) in normal brain using a multiphase arterial spin-labeling (ASL) magnetic resonance imaging (MRI) technique as a fundamental study to assess the temporal characteristics of perfusion SIs. Materials and methods Twenty temporal phases of a pulsed ASL-MRI [QUASAR, quantitative signal targeting by alternating radiofrequency pulses (STAR) labeling of arterial regions] in single-slice imaging were performed in 9 volunteers. Perfusion SIs were measured and TLPs were calculated in 14 regions of interest (ROIs), 7 in each hemisphere: thalamus, lentiform nucleus, medial frontal cortex in the anterior cerebral artery (ACA) territory, temporal cortex in the middle cerebral artery (MCA) territory, medial occipital cortex in the posterior cerebral artery (PCA) territory, anterior watershed region (AWR) and posterior watershed region (PWR). Results Mean TLP varied with ROI (region and mean ± standard deviation in seconds): thalamus, 1.60 ± 0.11; lentiform nucleus, 1.52 ± 0.11; ACA territory, 1.53 ± 0.16; MCA territory, 1.59 ± 0.18; PCA territory, 1.68 ± 0.20; AWR, 1.79 ± 0.14; PWR, 2.00 ± 0.20. TLP in the PWR was significantly longer than those in all other regions except the AWR, and TLP in the AWR was significantly longer than those in the lentiform nucleus and the ACA territory. Conclusion Our results revealed regional differences in the temporal characteristics of perfusion SIs on ASL-MRI.

    Original languageEnglish
    Pages (from-to)137-145
    Number of pages9
    JournalJapanese Journal of Radiology
    Volume30
    Issue number2
    DOIs
    Publication statusPublished - Feb 2012

    All Science Journal Classification (ASJC) codes

    • Radiology Nuclear Medicine and imaging

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