Approach for the development of new gene therapy method using cell signal transduction

Jeong Hun Kang, Kota Kodama, Jun Oishi, Kenji Kawamura, Takuro Niidome, Yoshiki Katayama

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.

    Original languageEnglish
    Pages2197
    Number of pages1
    Publication statusPublished - 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
    Duration: May 25 2005May 27 2005

    Other

    Other54th SPSJ Annual Meeting 2005
    Country/TerritoryJapan
    CityYokohama
    Period5/25/055/27/05

    All Science Journal Classification (ASJC) codes

    • General Engineering

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