TY - JOUR
T1 - Application of recombinant thioredoxin1 for treatment of heart disease
AU - Matsushima, Shouji
AU - Zablocki, Daniela
AU - Sadoshima, Junichi
N1 - Funding Information:
This work was supported in part by U.S. Public Health Service grants HL59139 , HL67724 , HL69020 , HL91469 , HL102738 , and AG27211 , and the Foundation of Leducq Transatlantic Network of Excellence .
PY - 2011/10
Y1 - 2011/10
N2 - Thioredoxin 1 (Trx1) is a small molecule with reactive cysteines that reduces proteins with disulfide bonds through a thiol disulfide exchange reaction. Accumulating lines of evidence suggest that Trx1 protects the heart from ischemia/reperfusion injury, pathological hypertrophy, and inflammation; induces preconditioning effects and angiogenesis; and upregulates mitochondrial genes. Exogenously given recombinant Trx1 (r-Trx1) may protect the heart through its actions in both extracellular and intracellular spaces. In this brief review, the potential of Trx1 therapy for heart disease is discussed. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure.".
AB - Thioredoxin 1 (Trx1) is a small molecule with reactive cysteines that reduces proteins with disulfide bonds through a thiol disulfide exchange reaction. Accumulating lines of evidence suggest that Trx1 protects the heart from ischemia/reperfusion injury, pathological hypertrophy, and inflammation; induces preconditioning effects and angiogenesis; and upregulates mitochondrial genes. Exogenously given recombinant Trx1 (r-Trx1) may protect the heart through its actions in both extracellular and intracellular spaces. In this brief review, the potential of Trx1 therapy for heart disease is discussed. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure.".
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U2 - 10.1016/j.yjmcc.2010.09.020
DO - 10.1016/j.yjmcc.2010.09.020
M3 - Review article
C2 - 20955713
AN - SCOPUS:80052810762
SN - 0022-2828
VL - 51
SP - 570
EP - 573
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
IS - 4
ER -