Appearance of focal cortical dysplasia on serial MRI after maturation of myelination

Fumiaki Yoshida, Takato Morioka, Kimiaki Hashiguchi, Yasushi Miyagi, Shinji Nagata, Yui Yamaguchi, Masaharu Ohfu, Tomio Sasaki

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Case report: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalChild's Nervous System
Issue number2
Publication statusPublished - Feb 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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