Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh; Jun Kuwahara; Kohji Itoh; Y. I. Fukuda; Mikiko Kohya; Mitsuru Shindo; Kozo Shishido

doi:10.1016/S0960-894X(02)00373-6

Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh
, Jun Kuwahara
, Kohji Itoh
, Y. I. Fukuda
, Mikiko Kohya
, Mitsuru Shindo
, Kozo Shishido

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

Original language	English
Pages (from-to)	2069-2072
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(02)00373-6
Publication status	Published - Aug 19 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(02)00373-6

Cite this

@article{5bfe113de3a848f3a8ce1080a5a4fe46,

title = "Apoptosis-Inducing activity of synthetic intermediates of Halichlorine",

abstract = "Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.",

author = "Midori Itoh and Jun Kuwahara and Kohji Itoh and Fukuda, \{Y. I.\} and Mikiko Kohya and Mitsuru Shindo and Kozo Shishido",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan. Financial support for K.S. was also provided by the Uehara Memorial Foundation. One of the authors (K.S.) is grateful for the generous financial support by the Uehara Memorial Foundation.",

year = "2002",

month = aug,

day = "19",

doi = "10.1016/S0960-894X(02)00373-6",

language = "English",

volume = "12",

pages = "2069--2072",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "16",

}

TY - JOUR

T1 - Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

AU - Itoh, Midori

AU - Kuwahara, Jun

AU - Itoh, Kohji

AU - Fukuda, Y. I.

AU - Kohya, Mikiko

AU - Shindo, Mitsuru

AU - Shishido, Kozo

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan. Financial support for K.S. was also provided by the Uehara Memorial Foundation. One of the authors (K.S.) is grateful for the generous financial support by the Uehara Memorial Foundation.

PY - 2002/8/19

Y1 - 2002/8/19

N2 - Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

AB - Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

UR - https://www.scopus.com/pages/publications/0037136021

UR - https://www.scopus.com/pages/publications/0037136021#tab=citedBy

U2 - 10.1016/S0960-894X(02)00373-6

DO - 10.1016/S0960-894X(02)00373-6

M3 - Article

C2 - 12127506

AN - SCOPUS:0037136021

SN - 0960-894X

VL - 12

SP - 2069

EP - 2072

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this