Apoptosis-Inducing activity of synthetic intermediates of Halichlorine

Midori Itoh, Jun Kuwahara, Kohji Itoh, Y. I. Fukuda, Mikiko Kohya, Mitsuru Shindo, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

Original languageEnglish
Pages (from-to)2069-2072
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number16
Publication statusPublished - Aug 19 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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