Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support

TERUHIKO IMAMURA, NIKHIL NARANG, G. E.N.E. KIM, DAISUKE NITTA, TAKEO FUJINO, A. N.N. NGUYEN, JONATHAN GRINSTEIN, DANIEL RODGERS, TAKEYOSHI OTA, VALLUVAN JEEVANANDAM, GABRIEL SAYER, N. I.R. URIEL

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Aortic insufficiency (AI) is associated with morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs), whereas its impact on the HeartMate 3 LVAD cohorts remains uninvestigated. We aimed to investigate the clinical impact of AI on patients with HeartMate 3 LVADs. Methods and Results: Consecutive 61 patients (median age 54 years; 67% male) implanted with HeartMate 3 LVAD between 2015 and 2019 were enrolled and underwent echocardiography at 3 months after LVAD implantation. AI severity was quantified by the novel Doppler echocardiographic method obtained at the outflow cannula and the calculated regurgitation fraction of 30% or greater (moderate or greater) was defined as significant. At 3 months after implant, 12 patients (20%) had significant AI. They had a higher incidence of death or heart failure readmissions compared with those without significant AI during a 1-year observational period (70% vs 24%, P = .003) with an adjusted hazard ratio of 2.76 (95% confidence interval 1.03–7.88). Conclusions: In patients with HeartMate 3 LVAD support, significant AI remains both prevalent and a clinically significant downstream complication.

Original languageEnglish
Pages (from-to)863-869
Number of pages7
JournalJournal of Cardiac Failure
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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