Anxa9 gene expression in colorectal cancer: A novel marker for prognosis

Norikatsu Miyoshi; Hirofumi Yamamoto; Koshi Mimori; Shinya Yamashita; Susumu Miyazaki; Sumiko Nakagawa; Hideshi Ishii; Shingo Noura; Masayuki Ohue; Masahiko Yano; Yuichiro Doki; Masaki Mori

doi:10.3892/ol.2014.2477

Anxa9 gene expression in colorectal cancer: A novel marker for prognosis

Norikatsu Miyoshi, Hirofumi Yamamoto, Koshi Mimori, Shinya Yamashita, Susumu Miyazaki, Sumiko Nakagawa, Hideshi Ishii, Shingo Noura, Masayuki Ohue, Masahiko Yano, Yuichiro Doki, Masaki Mori

Surgery

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.

Original language	English
Pages (from-to)	2313-2317
Number of pages	5
Journal	Oncology Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.3892/ol.2014.2477
Publication status	Published - Nov 1 2014

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ol.2014.2477

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abstract = "Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.",

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T1 - Anxa9 gene expression in colorectal cancer

T2 - A novel marker for prognosis

AU - Miyoshi, Norikatsu

AU - Yamamoto, Hirofumi

AU - Mimori, Koshi

AU - Yamashita, Shinya

AU - Miyazaki, Susumu

AU - Nakagawa, Sumiko

AU - Ishii, Hideshi

AU - Noura, Shingo

AU - Ohue, Masayuki

AU - Yano, Masahiko

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.

AB - Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.

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Anxa9 gene expression in colorectal cancer: A novel marker for prognosis

Abstract

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