TY - JOUR
T1 - ANTIOXIDANT AND ANTI-LIPASE COMPOUNDS ISOLATED FROM HEARTWOOD OF YAKUSHIMA NATIVE CEDAR (Cryptomeria japonica)
AU - Nakagawa, Toshinori
AU - Ashour, Ahmed
AU - Amen, Yhiya
AU - Ohnuki, Koichiro
AU - Fujimoto, Noboru
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
The authors appreciate the technical assistance from The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. They thank Mr. Katsuya Kawasaki (Yakushima-cho office, Kagoshima) and Mr. Kouji Takeda (Architectural Laboratory for Systems Environment Development Co., Ltd., Tokyo) for providing the samples.
Publisher Copyright:
©, Copyright © Taylor & Francis Group, LLC.
PY - 2019/9/3
Y1 - 2019/9/3
N2 - This article describes the biological activities of heartwood extracts from Yakushima native cedar (Cryptomeria japonica) and identifies their main active compounds. Black heartwood and red heartwood were each divided into two parts from the center (the pith) to outer heartwood (the cambium). The methanol extracts of those parts were screened for antioxidant and anti-lipase activities. The extract from the pith of the red heartwood showed the highest ORAC activity among the samples. Regarding anti-lipase activity, all the extracts showed relatively high activity (the IC50 value were 9.71–37.24 μg mL−1). In addition, four compounds were isolated and identified from the pith of red heartwood by NMR and MS analyses. Agatharesinol (3) and sequirin C (4) were thought to be the main active compounds responsible for the antioxidant and anti-lipase activities.
AB - This article describes the biological activities of heartwood extracts from Yakushima native cedar (Cryptomeria japonica) and identifies their main active compounds. Black heartwood and red heartwood were each divided into two parts from the center (the pith) to outer heartwood (the cambium). The methanol extracts of those parts were screened for antioxidant and anti-lipase activities. The extract from the pith of the red heartwood showed the highest ORAC activity among the samples. Regarding anti-lipase activity, all the extracts showed relatively high activity (the IC50 value were 9.71–37.24 μg mL−1). In addition, four compounds were isolated and identified from the pith of red heartwood by NMR and MS analyses. Agatharesinol (3) and sequirin C (4) were thought to be the main active compounds responsible for the antioxidant and anti-lipase activities.
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U2 - 10.1080/02773813.2019.1578806
DO - 10.1080/02773813.2019.1578806
M3 - Article
AN - SCOPUS:85063947924
SN - 0277-3813
VL - 39
SP - 305
EP - 312
JO - Journal of Wood Chemistry and Technology
JF - Journal of Wood Chemistry and Technology
IS - 5
ER -