Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia

Irawan Wijaya Kusuma, Enos Tangke Arung, Enih Rosamah, Sri Purwatiningsih, Harlinda Kuspradini, Syafrizal, Juli Astuti, Yong Ung Kim, Kuniyoshi Shimizu

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38 Citations (Scopus)


An active compound from the bulb of Eleutherine americana L. Merr. (Iridaceae) collected from East Kalimantan, Indonesia, was tested for its antidermatophyte and antimelanogenesis activity. Antifungal assay-directed fractionation of the n-hexane-soluble fraction of the methanolic extract of the bulb of E. americana led to the isolation of 1 as an active compound. The compound was identified as the naphthoquinone eleutherin by EI-MS and 1H-, 13C-, and two-dimensional NMR analyses. Antidermatophyte assay of 1 at concentrations of 10, 20, 40, 60, and 80 μg/disk and myconazole, a commercial antidermatophyte, at 10 μg/disk displayed 7, 8, 13, 16, 17, and 14 mm of inhibition zone against Trichophyton mentagrophytes, respectively. In a melanin formation inhibition assay, compound 1 displayed potent antimelanogenesis activity at 5 ppm with low toxicity compared with arbutin, a commercial skin-whitening agent. The results showed the high potential of 1, an active compound from E. americana, to be applied as an antidermatophyte and antimelanogenesis agent.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalJournal of Natural Medicines
Issue number2
Publication statusPublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Molecular Medicine


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