TY - JOUR
T1 - Anticarcinogenic effects of (-)-epigallocatechin gallate
AU - Fujiki, Hirota
AU - Yoshizawa, Seiji
AU - Horiuchi, Takahiko
AU - Suganuma, Masami
AU - Yatsunami, Jun
AU - Nishiwaki, Shinji
AU - Okabe, Sachiko
AU - Nishiwaki-Matsushima, Rie
AU - Okuda, Takuo
AU - Sugimura, Takashi
N1 - Funding Information:
’ This work was supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture, by a grant for the Program for a Comprehensive IO-Year Strategy for Cancer Control from the Ministry of Health and Welfare of Japan, and by grants from the Foundation for Promotion of Cancer Research, the Uehara Memorial Life Science Foundation, the Princess Takamatsu Cancer Research Fund, and the Smoking Research Foundation. * Presented at an International Symposium “Physiological and Pharmacological Effects of Camellia sinensis (Tea),” March 4 and 5, 1991, American Health Foundation, New York City. 3 To whom reprint requests should be addressed.
PY - 1992/7
Y1 - 1992/7
N2 - Background. Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin. Methods. We review (a) the inhibitory effect of penta-O-galloyl-β-d-glucose (5GG) on tumor promotion by teleocidin, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters (5GG is structurally similar to (-)-epigallocatechin gallate (EGCG) and is isolated from hydrolyzed tannic acid); (b) the inhibitory effects of EGCG, the main constituent of Japanese green tea, on tumor promotion with two tumor promoters, teleocidin and okadaic acid, a non-TPA-type tumor promoter; (c) the mechanisms of action of EGCG, a single application of which reduced the specific binding of [3H]TPA and [3H]okadaic acid to a particulate fraction of mouse skin; and (d) the anticarcinogenic effects of EGCG on duodenal carcinogenesis induced by N-ethyl-N′-nitro-N-nitrosoguanidine in male C57BL/6 mice. EGCG is a nontoxic compound. Conclusion. We believe that the main constituent of Japanese green tea, EGCG, is a practical cancer chemopreventive agent available in everyday life.
AB - Background. Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin. Methods. We review (a) the inhibitory effect of penta-O-galloyl-β-d-glucose (5GG) on tumor promotion by teleocidin, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters (5GG is structurally similar to (-)-epigallocatechin gallate (EGCG) and is isolated from hydrolyzed tannic acid); (b) the inhibitory effects of EGCG, the main constituent of Japanese green tea, on tumor promotion with two tumor promoters, teleocidin and okadaic acid, a non-TPA-type tumor promoter; (c) the mechanisms of action of EGCG, a single application of which reduced the specific binding of [3H]TPA and [3H]okadaic acid to a particulate fraction of mouse skin; and (d) the anticarcinogenic effects of EGCG on duodenal carcinogenesis induced by N-ethyl-N′-nitro-N-nitrosoguanidine in male C57BL/6 mice. EGCG is a nontoxic compound. Conclusion. We believe that the main constituent of Japanese green tea, EGCG, is a practical cancer chemopreventive agent available in everyday life.
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U2 - 10.1016/0091-7435(92)90057-O
DO - 10.1016/0091-7435(92)90057-O
M3 - Article
C2 - 1409491
AN - SCOPUS:0026705537
SN - 0091-7435
VL - 21
SP - 503
EP - 509
JO - Preventive Medicine
JF - Preventive Medicine
IS - 4
ER -
