Antibody internalization into living cells via crosslinker-mediated endocytosis

Daiki Funamoto; Daisuke Asai; Kazuki Sato; Yoko Yamaguchi; Chan Woo Kim; Hikari Sato; Elnaz Nakhaei; Shingo Matsumoto; Takuma Yoshikawa; Koichi Sasaki; Tatsuhiro Yamamoto; Akihiro Kishimura; Takeshi Mori; Yoshiki Katayama

doi:10.1246/cl.141157

Antibody internalization into living cells via crosslinker-mediated endocytosis

Daiki Funamoto, Daisuke Asai, Kazuki Sato, Yoko Yamaguchi, Chan Woo Kim, Hikari Sato, Elnaz Nakhaei, Shingo Matsumoto, Takuma Yoshikawa, Koichi Sasaki, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Chemistry Letters
Volume	44
Issue number	4
DOIs	https://doi.org/10.1246/cl.141157
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.141157

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title = "Antibody internalization into living cells via crosslinker-mediated endocytosis",

abstract = "We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.",

author = "Daiki Funamoto and Daisuke Asai and Kazuki Sato and Yoko Yamaguchi and Kim, {Chan Woo} and Hikari Sato and Elnaz Nakhaei and Shingo Matsumoto and Takuma Yoshikawa and Koichi Sasaki and Tatsuhiro Yamamoto and Akihiro Kishimura and Takeshi Mori and Yoshiki Katayama",

note = "Publisher Copyright: {\textcopyright} 2015 The Chemical Society of Japan.",

year = "2015",

doi = "10.1246/cl.141157",

language = "English",

volume = "44",

pages = "468--470",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "The Chemical Society of Japan",

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TY - JOUR

T1 - Antibody internalization into living cells via crosslinker-mediated endocytosis

AU - Funamoto, Daiki

AU - Asai, Daisuke

AU - Sato, Kazuki

AU - Yamaguchi, Yoko

AU - Kim, Chan Woo

AU - Sato, Hikari

AU - Nakhaei, Elnaz

AU - Matsumoto, Shingo

AU - Yoshikawa, Takuma

AU - Sasaki, Koichi

AU - Yamamoto, Tatsuhiro

AU - Kishimura, Akihiro

AU - Mori, Takeshi

AU - Katayama, Yoshiki

PY - 2015

Y1 - 2015

N2 - We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

AB - We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

UR - http://www.scopus.com/inward/record.url?scp=84929171042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929171042&partnerID=8YFLogxK

U2 - 10.1246/cl.141157

DO - 10.1246/cl.141157

M3 - Article

AN - SCOPUS:84929171042

SN - 0366-7022

VL - 44

SP - 468

EP - 470

JO - Chemistry Letters

JF - Chemistry Letters

IS - 4

ER -

Antibody internalization into living cells via crosslinker-mediated endocytosis

Abstract

All Science Journal Classification (ASJC) codes

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