Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats

Si Jing Chen, Chiwa Aikawa, Risa Yoshida, Tomoaki Kawaguchi, Toshiro Matsui

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


BACKGROUND: Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model. RESULTS: Spontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg kg–1 body weight day–1 for 12 weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and Nϵ-carboxymethyl-lysine residues (e.g. MG-H1, control: 465.5 ± 43.8 versus rose hip: 59.1 ± 13.0 pmol mg protein–1, P < 0.05) in SDT rats at the prediabetic stage (12–20 weeks old). CONCLUSION: The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model.

Original languageEnglish
Pages (from-to)3923-3928
Number of pages6
JournalJournal of the Science of Food and Agriculture
Issue number12
Publication statusPublished - Sept 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Agronomy and Crop Science
  • Nutrition and Dietetics


Dive into the research topics of 'Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats'. Together they form a unique fingerprint.

Cite this