Anti-inflammatory effects of kinins via microglia in the central nervous system

Mami Noda; Helmut Kettenmann; Keiji Wada

doi:10.1515/BC.2006.022

Anti-inflammatory effects of kinins via microglia in the central nervous system

Mami Noda, Helmut Kettenmann, Keiji Wada

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca²⁺, microglial migration, and increases the release of nitric oxide and prostaglandin E₂. On the other hand, BK attenuates lipopolysaccharide-activated TNF-α and IL-1β release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.

Original language	English
Pages (from-to)	167-171
Number of pages	5
Journal	Biological chemistry
Volume	387
Issue number	2
DOIs	https://doi.org/10.1515/BC.2006.022
Publication status	Published - Feb 2006

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Clinical Biochemistry

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10.1515/BC.2006.022

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title = "Anti-inflammatory effects of kinins via microglia in the central nervous system",

abstract = "Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin E2. On the other hand, BK attenuates lipopolysaccharide-activated TNF-α and IL-1β release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.",

author = "Mami Noda and Helmut Kettenmann and Keiji Wada",

note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science and from the Ministry of Health, Labor and Welfare, Japan. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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AB - Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin E2. On the other hand, BK attenuates lipopolysaccharide-activated TNF-α and IL-1β release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.

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Anti-inflammatory effects of kinins via microglia in the central nervous system

Abstract

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