Anti-inflammatory effect of HMG-CoA reductase inhibitors

Shiro Kitamoto, Kensuke Egashira

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


It has been suggested that HMG-CoA reductase inhibitors(statins) have additional cholesterol-independent pleiotropic effects on preventing coronary events and strokes. One of major pleiotropic actions of statins, which have been proposed, is anti-inflammatory effect. Statins have been shown to reduce infiltration of inflammatory cells into atherosclerotic lesions. It has been also reported that statins increase production of nitric oxide, reduce expression of proinflammatory cytokines and adhesion molecules, and lower plasma C-reactive protein levels. Although these effects may partially account for anti-inflammatory property of statins, its mechanisms are not fully understood. Therefore, further studies are expected to elucidate process of anti-inflammatory effect of statins.

Original languageEnglish
Pages (from-to)172-179
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number1
Publication statusPublished - Jan 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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