Anti-biofouling properties of polymers with a carboxybetaine moiety

Sulumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Geminei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property. A graph is presented.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalMacromolecular Bioscience
Issue number1
Publication statusPublished - Jan 9 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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