TY - JOUR
T1 - Anti-biofouling phosphorylated HEMA and PEGMA block copolymers show high affinity to hydroxyapatite
AU - Cui, Xinnan
AU - Murakami, Tatsuya
AU - Hoshino, Yu
AU - Miura, Yoshiko
N1 - Funding Information:
We are grateful to Prof. Hiroyuki Ijima, Dr. Shintaro Nakamura, Dr. Nana Shirakigawa, Dr. Midori Watanabe of Kyushu University and Dr. Alex Tanno and Prof. János Vörös of ETHZ. This study was supported by the Grant-in-Aid for Scientific Research B ( 15H03818 ) and Great-in-Aid for challenging Exploratory Research ( 16K14007 ).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Four types of phosphorylated 2-hydroxyethyl methacrylate and poly(ethylene glycol) methyl ether methacrylate (PEGMA) block copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and post-phosphorylation. These polymers were composed of different phosphate segments and similar PEG brushes. Polymers with defined phosphate segments were investigated to determine the optimal bonding affinity to hydroxyapatite (HAp). Polymers containing short phosphate segments (as low as 23 mer) were capable of immobilizing on HAp surfaces in situ in a short coating time with considerable durability. After surface modification, the dense PEG brushes altered the interfacial properties of HAp. The protein adsorption on the polymer-grafted HAp was drastically reduced compared with the bare HAp. Furthermore, the presence of the PEG brushes on the HAp surface resulted in bacterial inhibition. The polymer with the shortest phosphate segment (23 mer) showed superior inhibition ability.
AB - Four types of phosphorylated 2-hydroxyethyl methacrylate and poly(ethylene glycol) methyl ether methacrylate (PEGMA) block copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and post-phosphorylation. These polymers were composed of different phosphate segments and similar PEG brushes. Polymers with defined phosphate segments were investigated to determine the optimal bonding affinity to hydroxyapatite (HAp). Polymers containing short phosphate segments (as low as 23 mer) were capable of immobilizing on HAp surfaces in situ in a short coating time with considerable durability. After surface modification, the dense PEG brushes altered the interfacial properties of HAp. The protein adsorption on the polymer-grafted HAp was drastically reduced compared with the bare HAp. Furthermore, the presence of the PEG brushes on the HAp surface resulted in bacterial inhibition. The polymer with the shortest phosphate segment (23 mer) showed superior inhibition ability.
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U2 - 10.1016/j.colsurfb.2017.09.038
DO - 10.1016/j.colsurfb.2017.09.038
M3 - Article
C2 - 28946064
AN - SCOPUS:85029817228
SN - 0927-7765
VL - 160
SP - 289
EP - 296
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -