Anti-androgenic activities of Ganoderma lucidum

Rumi Fujita, Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Chie Ueda, Hisatoshi Tajiri, Shuhei Kaneko, Yoshitaro Suimi, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalJournal of Ethnopharmacology
Issue number1
Publication statusPublished - Oct 31 2005

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery


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