TY - JOUR
T1 - Anti-androgen effects of extracts and compounds from Ganoderma lucidum
AU - Liu, Jie
AU - Tamura, Sadaaki
AU - Kurashiki, Kenji
AU - Shimizu, Kuniyoshi
AU - Noda, Kiyoshi
AU - Konishi, Fumiko
AU - Kumamoto, Shoichiro
AU - Kondo, Ryuichiro
PY - 2009
Y1 - 2009
N2 - The 30% EtOH extracts of Ganoderma lucidum FR. KARST (Ganodermateceae) showed weak 5α-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.
AB - The 30% EtOH extracts of Ganoderma lucidum FR. KARST (Ganodermateceae) showed weak 5α-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.
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U2 - 10.1002/cbdv.200800019
DO - 10.1002/cbdv.200800019
M3 - Article
C2 - 19235153
AN - SCOPUS:64549145132
SN - 1612-1872
VL - 6
SP - 231
EP - 243
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 2
ER -
