Anisotropic, Degradable Polymer Assemblies Driven by a Rigid Hydrogen-Bonding Motif That Induce Shape-Specific Cell Responses

Kazuki Fukushima, Kodai Matsuzaki, Masashi Oji, Yuji Higuchi, Go Watanabe, Yuki Suzuki, Moriya Kikuchi, Nozomi Fujimura, Naofumi Shimokawa, Hiroaki Ito, Takashi Kato, Seigou Kawaguchi, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Poly(ethylene glycol)-conjugated amphiphilic block copolymers, which contain degradable hydrophobic blocks connected by a rigid hydrogen-bonding motif (RHM), are developed to yield anisotropic nanoassemblies in a manner independent of the crystalline nature of the hydrophobic block. The all-atom and coarse-grained molecular dynamics simulations suggest that the anisotropic alignment of the block copolymers can be attributed to the π-πinteractions of the RHM and the crystallizable hydrophobic blocks help maintain the aligned structure. Light scattering analysis of the polymer assemblies demonstrates the formation of nonspherical assemblies by the RHM-containing block copolymers with an amorphous hydrophobic block; this indicates the strong contribution of the RHM to the directed assembly of the block copolymers, unlike crystallization-driven self-assembly. Enhanced cell proliferation is observed in cell cultures containing normal human fibroblasts in the presence of the anisotropic polymer assemblies with aspect ratios greater than 12 or lengths greater than 310 nm.

Original languageEnglish
Pages (from-to)15-25
Number of pages11
JournalMacromolecules
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 11 2022

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Anisotropic, Degradable Polymer Assemblies Driven by a Rigid Hydrogen-Bonding Motif That Induce Shape-Specific Cell Responses'. Together they form a unique fingerprint.

Cite this