Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura; K. Yoshizawa; M. Kuwata; N. Uehara

Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura, K. Yoshizawa, M. Kuwata, N. Uehara

Research output: Contribution to journal › Review article › peer-review

Abstract

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.

Original language	English
Pages (from-to)	933-944
Number of pages	12
Journal	Histology and histopathology
Volume	25
Issue number	7
Publication status	Published - Jul 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.",

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AU - Yoshizawa, K.

AU - Kuwata, M.

AU - Uehara, N.

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AB - Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.

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ER -

Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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