Angiotensin II receptor and oxidative stress

Makoto Usui, Kensuke Egashira

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Angiotensin II(AngII) activates NADH/NAPDH oxidase activity and stimulates reactive oxygen species(ROS) production, which induces many proinflammatory genes such as vascular cell adhesion molecule-1(VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1(MCP-1) mainly via AngII type I receptor(AT1). ROS are important in cardiovascular disease because many of these preinflammatory cytokines play a critical role in the initiation and progression of atherosclerosis. AT1 receptor blockade is important to prevent cardiovascular disease. AngII type 1 receptor blocker(ARB) and/or AngII converting enzyme inhibitor(ACEI) are useful for preventing cardiovascular disease. The role of AngII type II receptor(AT2) for producing ROS and/or cardiovascular damage has been studied.

Original languageEnglish
Pages (from-to)1893-1897
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number10
Publication statusPublished - Oct 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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