TY - JOUR
T1 - Angiotensin II attenuates vascular contractility in the rabbit mesenteric artery
AU - Oike, Masahiro
AU - Takahashi, Naotsugu
AU - Ito, Yushi
N1 - Funding Information:
We thank Dr. K. Creed for critical reading of the manuscript. This work was supported in part by a grant-in-aid from the Ministry of Education of Japan.
PY - 1996/5/15
Y1 - 1996/5/15
N2 - We observed the effects of angiotensin II (AII) on the contractile response and the Ca2+ transient induced by high K+ solution in the rabbit mesenteric artery. In the control condition, the repented application of high K+ solution with 90 min interval induced a gradually increasing contraction, which was accompanied with a significant elevation of the intracellular calcium concentration ([Ca2+](i)). Treatment of the tissue with AII for one to two hours abolished the incremental response of the contraction. The change in [Ca2+](i) induced by high K+ solution, however, was not significantly different with and without treatment with AII. Pretreatment of the tissue with actinomycin D abolished the inhibitory action of AII on the incremental contraction, indicating the involvement of a transcriptional process. These results indicate that AII impairs vascular contractility through the modulation of Ca2+-sensitivity of the contractile machinery.
AB - We observed the effects of angiotensin II (AII) on the contractile response and the Ca2+ transient induced by high K+ solution in the rabbit mesenteric artery. In the control condition, the repented application of high K+ solution with 90 min interval induced a gradually increasing contraction, which was accompanied with a significant elevation of the intracellular calcium concentration ([Ca2+](i)). Treatment of the tissue with AII for one to two hours abolished the incremental response of the contraction. The change in [Ca2+](i) induced by high K+ solution, however, was not significantly different with and without treatment with AII. Pretreatment of the tissue with actinomycin D abolished the inhibitory action of AII on the incremental contraction, indicating the involvement of a transcriptional process. These results indicate that AII impairs vascular contractility through the modulation of Ca2+-sensitivity of the contractile machinery.
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U2 - 10.1006/bbrc.1996.0723
DO - 10.1006/bbrc.1996.0723
M3 - Article
C2 - 8670184
AN - SCOPUS:0030585358
SN - 0006-291X
VL - 222
SP - 208
EP - 214
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -