Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Naotsugu Oyama; Kazushi Urasawa; Satoshi Kaneta; Hidetsugu Sakai; Takahiko Saito; Chika Takagi; Ichiro Yoshida; Akira Kitabatake; Hiroyuki Tsutsui

doi:10.1253/circj.70.362

Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Naotsugu Oyama, Kazushi Urasawa, Satoshi Kaneta, Hidetsugu Sakai, Takahiko Saito, Chika Takagi, Ichiro Yoshida, Akira Kitabatake, Hiroyuki Tsutsui

Department of Angiocardiology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.

Original language	English
Pages (from-to)	362-363
Number of pages	2
Journal	Circulation Journal
Volume	70
Issue number	3
DOIs	https://doi.org/10.1253/circj.70.362
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1253/circj.70.362

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title = "Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients",

abstract = "Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.",

author = "Naotsugu Oyama and Kazushi Urasawa and Satoshi Kaneta and Hidetsugu Sakai and Takahiko Saito and Chika Takagi and Ichiro Yoshida and Akira Kitabatake and Hiroyuki Tsutsui",

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doi = "10.1253/circj.70.362",

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journal = "Circulation Journal",

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TY - JOUR

T1 - Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

AU - Oyama, Naotsugu

AU - Urasawa, Kazushi

AU - Kaneta, Satoshi

AU - Sakai, Hidetsugu

AU - Saito, Takahiko

AU - Takagi, Chika

AU - Yoshida, Ichiro

AU - Kitabatake, Akira

AU - Tsutsui, Hiroyuki

PY - 2006

Y1 - 2006

N2 - Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.

AB - Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.

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JO - Circulation Journal

JF - Circulation Journal

IS - 3

ER -

Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Abstract

All Science Journal Classification (ASJC) codes

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